1: Exp Biol Med (Maywood). 2005 Dec;230(11):865-71. Distinct host-dependent pathogenic mechanisms leading to a similar clinical anemia after infection with lymphocytic choriomeningitis virus. El-Azami-El-Idrissi M, Franquin S, Day MJ, Mazza G, Elson CJ, Préat V, Pfau CJ, Coutelier JP. Unit of Experimental Medicine, Institute for Cellular and Molecular Pathology, Université Catholique de Louvain, Bruxelles, Belgium. The Docile strain of lymphocytic choriomeningitis virus (LCMV) induces anemia in a number of inbred strains of mice, including C3HeB/FeJ and CBA/Ht animals. A difference in the kinetics of anemia and in compensatory reticulocytosis suggested that impaired erythropoiesis was the major pathogenic mechanism involved in CBA/Ht mice, but not in C3HeB/FeJ mice. In both mouse strains an antierythrocyte autoantibody production that depended on the presence of functional CD4+ T lymphocytes was observed. Although depletion of T helper lymphocytes prevented anemia in C3HeB/FeJ mice, this treatment largely failed to inhibit the development of the disease in CBA/Ht animals. This observation indicated that the antierythrocyte autoimmune response induced by the infection was at least partly responsible for the anemia of C3HeB/FeJ mice, but not of CBA/Ht mice. Erythrophagocytosis was enhanced in both mouse strains after LCMV infection, but did not appear to be a major cause of anemia. These data clearly indicate that similar disease profiles induced by the same virus in two different host strains can be the result of distinctly different mechanisms. PMID: 16339752 [PubMed - indexed for MEDLINE] Related Links Involvement of CD4+ cells in lymphocytic choriomeningitis virus-induced autoimmune anaemia and hypergammaglobulinaemia. [J Autoimmun. 1994] PMID:7840852 Lymphocytic choriomeningitis virus-induced alterations of T helper-mediated responses in mice developing autoimmune hemolytic anemia during the course of infection. [Proc Soc Exp Biol Med. 1998] PMID:9714079 Evidence for immune-mediated destruction as mechanism for LCMV-induced anemia in persistently infected mice. [Viral Immunol. 1991] PMID:1668061 Severe and transient pancytopenia associated with a chronic arenavirus infection. [J Exp Pathol. 1987] PMID:2835466 Infection of C3HeB/FeJ mice with the docile strain of lymphocytic choriomeningitis virus induces autoantibodies specific for erythrocyte Band 3. [Immunology. 1997] PMID:9227323