1: Bioorg Med Chem Lett. 2008 Aug 1;18(15):4291-3. Epub 2008 Jul 3.

Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for
biomedical EPR applications.

Driesschaert B, Charlier N, Gallez B, Marchand-Brynaert J.

Unité de Chimie Organique et Médicinale, Université catholique de Louvain, UCL,
place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.

Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in
biomedical magnetic resonance applications. We report a straightforward synthesis
of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15
and 45 fluorine atoms, and thus possessing a high affinity to fluorous media.
F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line
broadening is highly sensitive to molecular oxygen. These spin probes are
specially designed for assessment of tumor oxygenation using perfluorocarbon
formulations.


PMID: 18640034 [PubMed - indexed for MEDLINE]

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