1: Bioorg Med Chem Lett. 2008 Aug 1;18(15):4291-3. Epub 2008 Jul 3. Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications. Driesschaert B, Charlier N, Gallez B, Marchand-Brynaert J. Unité de Chimie Organique et Médicinale, Université catholique de Louvain, UCL, place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium. Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in biomedical magnetic resonance applications. We report a straightforward synthesis of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15 and 45 fluorine atoms, and thus possessing a high affinity to fluorous media. F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line broadening is highly sensitive to molecular oxygen. These spin probes are specially designed for assessment of tumor oxygenation using perfluorocarbon formulations. PMID: 18640034 [PubMed - indexed for MEDLINE] Related Links Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging. [Bioorg Med Chem Lett. 2007] PMID:17964156 Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals. [J Org Chem. 2006] PMID:16958520 In vivo imaging of free radicals: applications from mouse to man. [Mol Cell Biochem. 2002] PMID:12162454 General synthesis of persistent trityl radicals for EPR imaging of biological systems. [J Org Chem. 2002] PMID:12098269 2,3,5,6-Tetrafluorophenylnitren-4-yl: electron paramagnetic resonance spectroscopic characterization of a quartet-ground-state nitreno radical. [J Am Chem Soc. 2008] PMID:18327939