1: Antimicrob Agents Chemother. 2008 Apr 7. [Epub ahead of print] (2008) 52:2236–2238 Apoptosis induced by aminoglycosides in LLC-PK1 cells: comparison between neomycin, gentamicin, amikacin, and isepamicin using electroporation. Denamur S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM. Unité de Pharmacologie cellulaire et moléculaire, Université catholique de Louvain, B-1200 Brussels, Belgium. Aminoglycosides were compared for apoptosis induction (DAPI staining, activation of caspase 3) in renal LLC-PK1 cells. Amikacin caused less apoptosis than gentamicin in incubated cells. In electroporated cells, neomycin B and gentamicin caused apoptosis in the 0.06-0.1 mM range, isepamicin required larger concentrations (0.2 mM), and amikacin was without effect. PMID: 18391041 [PubMed - as supplied by publisher] Related Links Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. [Antimicrob Agents Chemother. 2006] PMID:16569831 Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. [Toxicol Appl Pharmacol. 2005] PMID:16039943 Aristolochic acid I-induced apoptosis in LLC-PK1 cells and amelioration of the apoptotic damage by calcium antagonist. [Chin Med J (Engl). 2000] PMID:11776096 Cadmium-bound metallothionein induces apoptosis in rat kidneys, but not in cultured kidney LLC-PK1 cells. [Life Sci. 1999] PMID:10075112 Effect of aminoglycoside antibiotics on cellular functions of kidney epithelial cell line (LLC-PK1): a model system for aminoglycoside nephrotoxicity. [J Pharmacol Exp Ther. 1984] PMID:6088764