1: J Pharm Belg  2001 Mar-Apr;56(2):33-7

[Interactions of food and drug metabolism]

[Article in French]

Delzenne NM, Verbeeck RK.

Unite de Pharmacocinetique, Metabolisme, Nutrition et Toxicologie, Ecole de
Pharmacie Universite Catholique de Louvain MD/FARM/PMNT 7369, Avenue Emmanuel
Mounier, 73 B-1200 Bruxelles. Delzenne@pmnt.ucl.ac.be

The nutritional state, and/or the ingestion of specific nutrients, is/are able
to modify drug disposition, by interfering with drug absorption, distribution,
storage, and metabolism. Recent data report that nutrients interfere with drug
metabolism either by modifying key enzymes of phase I (cytochromeP450 dependent
mixed function oxidase) and II (glucuronosyl, sulfonyl- ... transferases), or by
modulating coenzymes availability (NADPH, UDPglucuronic acid...). Food
components involved in drug metabolism modifications are either macro-nutrients
(carbohydrates, lipids, proteins, ethanol), micronutriments (vitamins,
minerals), or phytochemicals. Drug-nutrients interactions may be beneficials,
and thus could constitute, i.e. a way to improve drug therapeutic index, or
generate adverse effects.

Publication Types:
Review
Review, Tutorial

PMID: 11396348 [PubMed - indexed for MEDLINE]