1: Life Sci. 2006 Aug 1;79(10):1007-13. Epub 2006 May 20.

Relation between colonic proglucagon expression and metabolic response to
oligofructose in high fat diet-fed mice.

Delmee E, Cani PD, Gual G, Knauf C, Burcelin R, Maton N, Delzenne NM.

Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite
catholique de Louvain, Brussels, Belgium.

Several data suggest that fermentable dietary fiber could play a role in the
control of obesity and associated metabolic disorders. The aim of this study was
to investigate the putative role of short chain fructo-oligosaccharide (OFS) - a
non-digestible oligosaccharide - in mice fed a standard diet and in mice fed two
distinct high fat diets inducing metabolic disorders associated to obesity. We
confirmed, in mice, several effects previously shown in rats fed a standard diet
enriched with OFS, namely an increase in total and empty caecum weight, a
significant decrease in epididymal fat mass, and an increase in colonic and
portal plasma glucagon-like peptide-1 (GLP-1), a phenomenon positively
correlated with a higher colonic proglucagon mRNA level. Curiously, 4-week
treatment with OFS added at the same dose induced different effects when added
in the two different high fat diets. OFS decreased energy intake, body weight
gain, glycemia, and epididymal fat mass only when added together with the high
fat-carbohydrate free diet, in which OFS promoted colonic proglucagon expression
and insulin secretion. Our results support an association between the increase
in proglucagon expression in the proximal colon and OFS effects on glycemia, fat
mass development, and/or body weight gain. In conclusion, dietary
oligosaccharides would constitute an interesting class of dietary fibers
promoting, in certain conditions, endogenous GLP-1 production, with beneficial
physiological consequences. This remains to be proven in human studies.

PMID: 16757002 [PubMed - indexed for MEDLINE]

Related Links

    Oligofructose promotes satiety in rats fed a high-fat diet: involvement of
glucagon-like Peptide-1. [Obes Res. 2005] PMID:15976142
    
    Involvement of endogenous glucagon-like peptide-1(7-36) amide on
glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. [J
Endocrinol. 2005] PMID:15930172
    
    Improvement of glucose tolerance and hepatic insulin sensitivity by
oligofructose requires a functional glucagon-like peptide 1 receptor. [Diabetes.
2006] PMID:16644709
    
    Inulin-type fructans modulate gastrointestinal peptides involved in appetite
regulation (glucagon-like peptide-1 and ghrelin) in rats. [Br J Nutr. 2004]
PMID:15469657
    
    Effect of non-digestible gluco-oligosaccharides on glucose sensitivity in
high fat diet fed mice. [J Physiol Biochem. 2003] PMID:15000447