ARTICLE AUTHOR: Dechamps-M; Sonveaux-E

REPRINT AUTHOR: Sonveaux, E; UNIV CATHOLIQUE LOUVAIN; SCH PHARM, UCL 7340, AVE E MOUNIER 73; B-1200 BRUSSELS; BELGIUM

SOURCE: NUCLEOSIDES-AND-NUCLEOTIDES. APR 1998; 17 (4) : 697-709

ABSTRACT:

The synthesis of a new phosphoramidite building block with a masked aldehyde function is described. It was incorporated in an oligodeoxyribonucleotide. Coupling to amino derivatives by reductive amination was performed in high yield after unmasking the aldehyde function.