ARTICLE AUTHOR: Dechamps-M; Sonveaux-E

REPRINT AUTHOR: Sonveaux, E; UNIV CATHOLIQUE LOUVAIN; UCL 7340, AVE E MOUNIER 73; B-1200 BRUSSELS; BELGIUM

SOURCE: NUCLEOSIDES-AND-NUCLEOTIDES. 1995; 14 (3-5) : 867-870

ABSTRACT:

new nucleoside analogs with a masked aldehyde function have been synthesized and incorporated in oligodexoyribonucleotides. After unmasking the aldehyde function, the oligomers were easily coupled to biotin derivatives by reductive amination. Reversed phase HPLC proved to be an unvaluable tool to characterize and purify these conjugates.