Radiostability of pharmaceuticals under different irradiation conditions
Radiation Physics and Chemistry 72 (2005) 355-361
Anne-Sophie Crucq, Véronique Deridder and Bernard Tilquin,
In this paper, the products studied are cefazolin, glucagon and
dobutamine HCl. The radioresistance of pharmaceuticals may depend on
the conditions of irradiation. The best is to irradiate the drugs in
solid state and the chemical transformations can be reduced also by
lowering the temperature of the liquid. In solid state, the dose rate
has no influence on the decomposition for the selected molecules and it
should be noted that drug excipients selected for bioavailability
reasons are not always radioprotectors. These results are important
from a technical point of view in pharmaceutical industry.
Keywords: Gamma irradiation; Electron-beam irradiation;
Radiosensitivity; Cefazolin; Glucagon; Dobutamine HCl; Pharmaceuticals;
Radiosterilization