1: Magn Reson Imaging. 2009 May;27(4):565-9. Epub 2008 Sep 20.

Assessment of liver phagocytic activity using EPR spectrometry and imaging.

Charlier N, Neyrinck AM, Beghein N, Delzenne NM, Gallez B.

Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Université
catholique de Louvain, 1200 Brussels, Belgium.

The aim of the present study was to evaluate the usefulness of electron
paramagnetic resonance (EPR) spectroscopy and imaging in assessing the phagocytic
activity of the liver after administration of India ink. We conducted experiments
on livers from control rodents and from rodents in which the Kupffer cell
population had been depleted by pretreatment with gadolinium chloride. The EPR
signal intensity recorded in liver homogenates was about two times lower in
GdCl(3) treated rats than in control rats. EPR imaging carried out on
precision-cut liver slices indicated a good correlation between the depletion of 
Kupffer cells and the EPR signal intensity.


PMID: 18805665 [PubMed - in process]

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