1: Obes Res. 2005 Jun;13(6):1000-7. 

Oligofructose promotes satiety in rats fed a high-fat diet: involvement of
glucagon-like Peptide-1.

Cani PD, Neyrinck AM, Maton N, Delzenne NM.

Universite Catholique de Louvain-Unite de Pharmacocinetique, Metabolisme,
Nutrition et Toxicologie 7369, 73 Avenue Mounier, B-1200 Brussels, Belgium.

OBJECTIVE: To analyze the putative interest of oligofructose (OFS) in the
modulation of food intake after high-fat diet in rats and to question the
relevance of the expression and secretion of intestinal peptides in that
context. RESEARCH METHODS AND PROCEDURES: Male Wistar rats were pretreated with
standard diet or OFS-enriched (10%) standard diet for 35 days followed by 15
days of high-fat diet enriched or not with OFS (10%) treatment. Body weight,
food intake, triglycerides, and plasma ghrelin levels were monitored during the
treatment. On day 50, rats were food-deprived 8 hours and anesthetized for blood
and intestinal tissue sampling for further proglucagon mRNA, glucagon-like
peptide (GLP)-1, and GLP-2 quantification. RESULTS: The addition of OFS in the
diet protects against the promotion of energy intake, body weight gain, fat mass
development, and serum triglyceride accumulation induced by a high-fat diet. OFS
fermentation leads to an increase in proglucagon mRNA in the cecum and the colon
and in GLP-1 and GLP-2 contents in the proximal colon, with consequences on the
portal concentration of GLP-1 (increase). A lower ghrelin level is observed only
when OFS is added to the standard diet of rats. DISCUSSION: In rats exposed to
high-fat diet, OFS is, thus, able to modulate endogenous production of gut
peptides involved in appetite and body weight regulation. Because several
approaches are currently used to treat type 2 diabetes and obesity with limited
effectiveness, dietary fibers such as OFS, which promote the endogenous
production of gut peptides like GLP-1, could be proposed as interesting
nutrients to consider in the management of fat intake and associated metabolic
disorders.

PMID: 15976142 [PubMed - in process]