1: J Nutr. 2007 Nov;137(11):2534S-2538S.

Glucagon-Like Peptide-1 and Energy Homeostasis.

Burcelin R, Cani PD, Knauf C.

Institute of Molecular Medicine Rangueil IMR, INSERM 858, Université Paul
Sabatier, IFR31, CHU Rangueil, 31432 Toulouse Cedex 4, France 5Unit of
Pharmacokinetics, Metabolism, Nutrition and Toxicology, Université Catholique de 
Louvain, 1200 Brussels, Belgium.

A growing body of evidence demonstrates the role of gut-derived hormones in the
control of energy homeostasis. Among those intestinal signals, physiological and 
therapeutic interest has been drawn to glucagon-like peptide-1 (GLP-1). The main 
reasons are that this hormone 1) is secreted by epithelial intestinal L-cells in 
response to glucose and lipids, 2) enhances glucose-stimulated insulin secretion,
3) improves blood glucose profiles of type 2 diabetic patients by means of
several actions on pancreatic hormone secretions, 4) reduces body weight and food
intake, and 5) slows gastric emptying. Furthermore, recent evidence has suggested
that the nervous system is a key player accounting for the beneficial role of
GLP-1 on the control of energy homeostasis. Hence, the role of GLP-1 on the
gut-to-brain axis is reviewed.

PMID: 17951498 [PubMed - as supplied by publisher]

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