1: J Nutr. 2007 Nov;137(11):2534S-2538S. Glucagon-Like Peptide-1 and Energy Homeostasis. Burcelin R, Cani PD, Knauf C. Institute of Molecular Medicine Rangueil IMR, INSERM 858, Université Paul Sabatier, IFR31, CHU Rangueil, 31432 Toulouse Cedex 4, France 5Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Université Catholique de Louvain, 1200 Brussels, Belgium. A growing body of evidence demonstrates the role of gut-derived hormones in the control of energy homeostasis. Among those intestinal signals, physiological and therapeutic interest has been drawn to glucagon-like peptide-1 (GLP-1). The main reasons are that this hormone 1) is secreted by epithelial intestinal L-cells in response to glucose and lipids, 2) enhances glucose-stimulated insulin secretion, 3) improves blood glucose profiles of type 2 diabetic patients by means of several actions on pancreatic hormone secretions, 4) reduces body weight and food intake, and 5) slows gastric emptying. Furthermore, recent evidence has suggested that the nervous system is a key player accounting for the beneficial role of GLP-1 on the control of energy homeostasis. Hence, the role of GLP-1 on the gut-to-brain axis is reviewed. PMID: 17951498 [PubMed - as supplied by publisher] Related Links Is glucagon-like peptide 1 an incretin hormone? [Diabetologia. 1999] PMID:10096792 The incretins: a link between nutrients and well-being. [Br J Nutr. 2005] PMID:15877888 Biological actions and therapeutic potential of the glucagon-like peptides. [Gastroenterology. 2002] PMID:11832466 [Glucagon-like peptides--synthesis, biological actions and some clinical implications] [Przegl Lek. 2004] PMID:15803906 Biologic actions and therapeutic potential of the proglucagon-derived peptides. [Nat Clin Pract Endocrinol Metab. 2005] PMID:16929363