ARTICLE AUTHOR: Bouzin-C; Brouckaert-S; Cottem-D; Berens-C; Sonveaux-E

REPRINT AUTHOR: Sonveaux, E; UNIV CATHOLIQUE LOUVAIN; PHARMACEUT CHEM AND RADIOPHARM UNIT, UCL 7340, AVE E MOUNIER 73; B-1200 BRUSSELS; BELGIUM

SOURCE: BIOORGANIC-AND-MEDICINAL-CHEMISTRY-LETTERS. AUG 5 1997; 7 (15) : 2071-2076

ABSTRACT:

Phosphorothioates kill the procyclic form of T. brucei brucei by a non antisense but sequence dependent effect. The alamar Blue(TM) method allowed an easy microscale determination of their antiparasitic effect. The LD50 of the sequences tested was in the range of 11-20 mu M. (C) 1997 Elsevier Science Ltd.