Planta Med  2002 Jul;68(7):647-9 



ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus.



Block S, Stevigny C, De Pauw-Gillet MC, de Hoffmann E, Llabres G, Adjakidje V,

Quetin-Leclercq J.



The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae)

showing in vitro cytotoxicity against human cervix carcinoma cells was

investigated in order to identify its active compounds. A bio-guided

fractionation by HSCCC followed by MPLC led us to isolate a trachylobane

diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa

cells = 7.3 microg/ml). This is the first report on the cytotoxicity of a

trachylobane diterpene.



Publication Types:

    Letter


PMID: 12143003 [PubMed - indexed for MEDLINE]