ARTICLE AUTHOR: Barbarin-N; Crucq-AS; Tilquin-B

REPRINT AUTHOR: Barbarin, N; UNIV CATHOLIQUE LOUVAIN; UNITE ANAL CHIM AND PHYSICOCHEM MED, CHAM 72 30, 72 AVE E MOUNIER; B-1200 BRUSSELS; BELGIUM

SOURCE: RADIATION-PHYSICS-AND-CHEMISTRY. DEC 1996; 48 (6) : 787-794

ABSTRACT:

The use of gamma-rays is a promising method to sterilize thermosensitive drugs. Although radiosterilization does not modify drugs activity, this mode of sterilization produces new radiolytic products. This study is devoted to the analysis of volatile compounds which may induce a modification of odour. The volatile compounds produced by radiolysis of cefotaxime, cefuroxime and ceftazidime, three cephalosporins, were analyzed by gas chromatography with headspace sampling. They were detected and identified by mass and infrared spectrometry. An explanation of their origin is proposed. Copyright (C) 1996 Elsevier Science Ltd