Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats.
Bailleux V, Vallee L, Nuyts JP, Hamoir G, Poupaert JH, Stables JP, Vamecq J
North France Center for the Study of Childhood Epilepsy, Centre Hospitalier Universitaire et Faculte de Medecine de Lille.
We compared the anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide
(ADD 213063) with those of phenytoin (PHT), carbamazepine (CBZ), phenobarbital
(PB), ethosuximide (ESM), valproate (VPA), and felbamate (FBM). Evaluation
of anticonvulsant properties performed according to well-established procedures
in rats and mice showed that ADD 213063 is most effective in protecting
animals against maximal electroshock seizures (MES). This anti-MES activity
is achieved with nontoxic doses, with the optimal effect recorded in rats
dosed orally with anti-MES ED50 and protective index (PI) values of 25.2
mumol/kg and > 75, respectively. ADD 213063 protects to a lesser extent
against seizures induced by subcutaneous (s.c.) picrotoxin and subcutaneous
pentylenetetrazol (PTZ) in mice dosed intraperitoneally and orally, respectively.
The profile of anticonvulsant action of ADD 213063 closely parallels that
of CBZ.
PMID: 7555967, UI: 96032590